Thiophenol → HCID 178439287, compound

HRID 1722265Notes

Reaction equation

HRID 1722265 reaction equation
[CH3:1][C:2]1[CH:7]([O:8][C:9]([CH:11]2[C:13]([CH3:15])([CH3:14])[CH:12]2[CH:16]=[C:17]([CH3:19])[CH3:18])=[O:10])[CH2:6][C:4](=[O:5])[C:3]=1[CH2:20][C:21]#[CH:22].[NH2:23][C@H:24]([C:32]([NH:34][C@H:35]([C:54]([OH:56])=[O:55])[CH2:36][C:37]1[N:41]=[CH:40][N:39](C2C=CC([N+]([O-])=O)=CC=2[N+]([O-])=O)[CH:38]=1)=[O:33])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH:57]1([CH2:63][C@H:64]([NH-:75])[CH:65]([OH:74])[CH2:66][C:67]2[O:68][CH2:69][C:70]([CH3:73])([CH3:72])[N:71]=2)[CH2:62][CH2:61][CH2:60][CH2:59][CH2:58]1.C1(S)C=CC=CC=1>>[CH3:1][C:2]1[CH:7]([O:8][C:9]([CH:11]2[C:13]([CH3:14])([CH3:15])[CH:12]2[CH:16]=[C:17]([CH3:19])[CH3:18])=[O:10])[CH2:6][C:4](=[O:5])[C:3]=1[CH2:20][C:21]#[CH:22].[NH2:23][C@H:24]([C:32]([NH:34][C@H:35]([C:54]([OH:56])=[O:55])[CH2:36][C:37]1[N:41]=[CH:40][NH:39][CH:38]=1)=[O:33])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH:57]1([CH2:63][C@H:64]([NH-:75])[CH:65]([OH:74])[CH2:66][C:67]2[O:68][CH2:69][C:70]([CH3:73])([CH3:72])[N:71]=2)[CH2:62][CH2:61][CH2:60][CH2:59][CH2:58]1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 131716028HCID 131716028, compound

Product 1

HCID 178439287HCID 178439287, compound

Procedure

300 mg of Etoc-Phe-His(DNP)-1(S)-cyclohexylmethyl-2(R,S)-hydroxy-3-(4,4-dimethyloxazolin-2yl)propylamide are reacted with thiophenol to give the title compound in analogy to reference example 1(a).

Sources & evidence

ORD record
ord-a7d9f8c48e154a3b88a65f42ff2cc179
Source dataset
uspto-grants-1989_08
Patent number
US04855286

Reaction notes

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