Water → Boc-1(S)-Cyclohexylmethyl-2(R,S)-hydroxy-4-(2-pyridyl)butylamine

Participants

Reaction Steps

220 μl of 2-picoline (2 eq) are deprotonated in analogy to Example (6c). Then 300 mg of Boc-2-cyclohexyl-1(S)-oxiran-2(R,S)-ylethylamine in THF are added dropwise at -60° C. After 1 h, H2O is added, and the mixture is extracted 3 times with EA. The organic phases are dried with Na2 so4 and then concentrated, and the title compound is isolated by chromatography on SiO2 with EA/H 2:1 as eluent.

Provenance & Evidence