反应详情

To 3-(t-butoxycarbonylamino)-1-benzyl-4-methylpyrrolidine (3.9 g) are added ethanol (50 ml) and 10% Pd-C (780 mg), and the mixture is subjected to catalytic reduction at 60° C. under atmospheric pressure. After the catalytic reduction, the catalyst is removed off by filtration, and the filtrate is concentrated. The resulting residue is recrystallized from ethyl acetate-petroleum ether to give 3-(t-butoxycarbonylamino)-4-methylpyrrolidine (isomer A) (2.01 g), as colorless prisms, m.p. 86.8°-87° C.

1. customis subjected to catalytic reduction at 60° C. under atmospheric pressure
2. customAfter the catalytic reduction, the catalyst is removed off by filtration
3. concentrationthe filtrate is concentrated
4. customThe resulting residue is recrystallized from ethyl acetate-petroleum ether