p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

361 mg of the N-protected compound obtained in (a) and 360 mg of anisole were dissolved in 4 ml of acetic acid, and 270 mg of p-toluenesulfonic acid monohydrate was added. The mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated to dryness under reduced pressure. Water and benzene were added to the residue, and the aqueous layer was separated. The aqueous layer was washed with benzene and lyophilized to give 350 mg of the p-toluenesulfonate of the captioned compound as a colorless solid.

Provenance & Evidence