HCID 13825248, compound → HCID 70045625, compound

Participants

Reaction Steps

An approximately 1:1 mixture (270 mg) of 2,2-difluoro-(R)-3-hydroxy-(S)-4-amino-5-cyclohexyl-N-methylvaleramide and 2,2-difluoro-(S)-3-hydroxy-(S)-4-amino-5-cyclohexyl-N-methylvaleramide obtained from 2,2-difluoro-(R,S)-3-hydroxy-4-t-butoxycarbonylamino-5-cyclohexyl-valeramide ethyl ester was treated according to the procedure of Example 1 with triethylamine, Mor-Phe-Nle, HBT and DCC to give, after identical workup and chromatography, the title substance (266 mg, 47%) which was well separated from the slightly less polar isomer (product of Example 1 (160 mg, 28%).

Provenance & Evidence