2,6-Difluorobenzoyl isocyanate → HCID 20028635, compound

HRID 1722317Notes

Reaction equation

HRID 1722317 reaction equation
[Cl:1][C:2]1[C:3]([O:12][C:13]2[C:18]([Cl:19])=[CH:17][C:16]([N:20]=[C:21]=[O:22])=[CH:15][C:14]=2[Cl:23])=[N:4][CH:5]=[C:6]([O:8][CH:9]([F:11])[F:10])[CH:7]=1.[F:24][C:25]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:26]=1[C:27]([N:29]=[C:30]=[O:31])=[O:28]>CCCCCCC>[Cl:1][C:2]1[C:3]([O:12][C:13]2[C:18]([Cl:19])=[CH:17][C:16]([N:20]3[C:21](=[O:22])[O:28][C:27]([C:26]4[C:25]([F:24])=[CH:35][CH:34]=[CH:33][C:32]=4[F:36])=[N:29][C:30]3=[O:31])=[CH:15][C:14]=2[Cl:23])=[N:4][CH:5]=[C:6]([O:8][CH:9]([F:10])[F:11])[CH:7]=1

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 20028634HCID 20028634, compound

Product 1

HCID 20028635HCID 20028635, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

0.8 g (2.2 mmol) of 4-(3-chloro-5-difluoromethoxy-2-pyridyloxy)-3,5-dichlorophenyl isocyanate and 0.4 g (2.2 mmol) of 2,6-difluorobenzoyl isocyanate were stirred for 16 hours at 70° C. with the exclusion of moisture, and, after cooling, the solid formed was stirred with 5 ml of absolute n-heptane, filtered off under suction and recrystallized from cyclohexene/toluene; melting point 154°-6° C., yield: 86%.

Workup

  1. temperatureafter cooling
  2. customthe solid formed
  3. filtrationfiltered off under suction
  4. customrecrystallized from cyclohexene/toluene

Sources & evidence

ORD record
ord-0d123d3272d847b6973a5897423510ad
Source dataset
uspto-grants-1989_08
Patent number
US04855309

Reaction notes

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