反应详情

To 1ml of toluene was added 0.1g (0.35 mol) of the product of Example 4, 0.11g (0.38 mmol) of the product of Example 9, and 5.0mg of tetrakis(triphenylphosphine)palladium(O). The solution was degassed with argon and then heated at reflux under argon for approximately 5 hours. The reaction mixture was then cooled to room temperature and flash chromatographed. Gradient elution with hexane, 1% diethyl ether in hexane, 5% diethyl ether in hexane, and 10% diethyl ether in hexane produced 0.90mg (0.19 mmol) of the titled product.

1. customThe solution was degassed with argon
2. temperatureheated
3. temperatureat reflux under argon for approximately 5 hours
4. customflash chromatographed
5. washGradient elution with hexane, 1% diethyl ether in hexane, 5% diethyl ether in hexane