Ammonia → HCID 20028765, compound

HRID 1722358Notes

Reaction equation

HRID 1722358 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:20][CH:21]([OH:30])[CH2:22][S:23][CH2:24][CH2:25][C:26](OC)=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:31]>CO>[CH2:1]([O:8][C:9]1[C:14]([CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:20][CH:21]([OH:30])[CH2:22][S:23][CH2:24][CH2:25][C:26]([NH2:31])=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14421499HCID 14421499, compound

Product 1

HCID 20028765HCID 20028765, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g of methyl 7-(2-benzyloxy-3-cyclopentylphenyl)-6-hydroxy-4-thiaheptanoate (Example 1) is dissolved in 20 ml of an approximately 10% strength solution of ammonia in methanol, and the solution is left to stand in a closed vessel at room temperature for 7 days. The solvent is removed by distillation in vacuo, and the residue is purified by column chromatography on silica gel (mobile phase ethyl acetate/cyclohexane 1:4).

Workup

  1. waitthe solution is left
  2. customThe solvent is removed by distillation in vacuo
  3. customthe residue is purified by column chromatography on silica gel (mobile phase ethyl acetate/cyclohexane 1:4)

Sources & evidence

ORD record
ord-ef00271696a847b39fefb6acd4f21a35
Source dataset
uspto-grants-1989_08
Patent number
US04855323

Reaction notes

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