Potassium Hydroxide → HCID 14180954, compound

Participants

Reaction Steps

A solution of ethyl 4-[[(methylsulphonyl)amino]methyl]benzeneacetate (3.1 g) and 1M KOH (22 ml) in ethanol (50 ml) was stirred at room temperature for 3 h and evaporated in vacuo to leave an off-white solid. This solid was dissolved in water (50 ml) and washed with EA (2×50 ml). The organic extract was discarded and the aqueous layer was acidified (pH1) with 5M hydrochloric acid (about 10 ml) to precipitate the title compound (2.54 g) as a white solid m.p. 167°-169°.

Provenance & Evidence