Hydrochloric Acid → HCID 14180973, compound

Participants

Reaction Steps

The compound of Section (b) (6.25 g) was suspended in a mixture of water (17 ml) and concentrated hydrochloric acid (8.5 ml). The mixture was cooled in an ice bath and a solution of sodium nitrite (1.39 g) in water (8.5 ml) was added dropwise. The reaction mixture was stirred in the ice bath for 10 min to give a yellow solution with a fine suspension. The suspension was removed by filtration and the filtrate was collected in a cool receiver. The fltrate was poured into a solution of tin (II) chloride (20.6 g) in concentrated hydrochloric acid (8.5 ml) to give a yellow gum, which was removed and dissolved in ethanol (100 ml). The ethanol solution was evaporated in vacuo and re-evaporation with toluene gave a yellow gum. This gum was triturated with ER (250 ml) to give the title compound (9.36 g) as a pale yellow solid.

Provenance & Evidence