Dimethylamine → HCID 14180976, compound

HRID 1722427Notes

Reaction equation

HRID 1722427 reaction equation
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH2:13][CH2:14][NH:15][C:16](=[O:26])[CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:11]=2)[NH:6][CH:5]=1.[CH3:27][NH:28][CH3:29]>>[CH3:27][N:28]([CH3:29])[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH2:13][CH2:14][NH:15][C:16](=[O:26])[CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:11]=2)[NH:6][CH:5]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 14180975HCID 14180975, compound

Product 1

HCID 14180976HCID 14180976, compound

Procedure

A solution of the product of Section (b) (117 mg) in ethanolic dimethylamine (33% w/w; 10 ml) was stirred at room temperature for 19 h. The solvent was removed in vacuo and the residue purified by `flash` chromatography (C) to give the title compound of the invention as a colourless oil (96 mg). T.l.c. (C), Rf 0.27.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by `flash` chromatography (C)

Sources & evidence

ORD record
ord-1dc54aecae164116a9b4f2f41fd12489
Source dataset
uspto-grants-1989_08
Patent number
US04855314

Reaction notes

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