Methanol → 1,5,5-Trimethyl-2-pyrrolidinone

HRID 1722450Notes

Reaction equation

HRID 1722450 reaction equation
[CH3:1][C:2]1([CH3:8])[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.[CH3:9]O>>[CH3:9][N:6]1[C:2]([CH3:8])([CH3:1])[CH2:3][CH2:4][C:5]1=[O:7]

Participants

3

Reactant 2

HCID 887MethanolHCID 111262105,5-Dimethylpyrrolidin-2-one

Product 1

HCID 4445701,5,5-Trimethyl-2-pyrrolidinoneYield 86%

Procedure

A solution of 113 g (1 mole) of 5,5-dimethylpyrrolid-2-one and 96 g (3 moles) of methanol was vaporized, and passed over an alumina catalyst at 400° C. Working up the gas mixture in a conventional manner to obtain 1,5,5-trimethylpyrrolid-2-one gives this compound in about 86% yield; boiling point: 236°-238° C.

Workup

  1. custompassed over an alumina catalyst at 400° C

Sources & evidence

ORD record
ord-e1e0b9edf9d54ffd93f31bfcfa64dd54
Source dataset
uspto-grants-1989_08
Patent number
US04855444

Reaction notes

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