HCID 12642256, compound → HCID 14720887, compound
Reaction equation
C(O[C:4](=[O:10])[C@H:5]([N:7]=[N+:8]=[N-:9])[CH3:6])C>C(N)(C)C>[CH:5]([NH:7][C:4](=[O:10])[CH:5]([N:7]=[N+:8]=[N-:9])[CH3:6])([CH3:6])[CH3:4]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A 14.3 g sample of (R)-ethyl-2-azidopropionate was taken up in 50 mL of isopropylamine and allowed to stand for 24 hours. After stripping excess amine, 14.8 g of pure N-isopropyl-2-azidopropionamide was obtained. The amide thus obtained, 3.12 g, was stirred with 5.0 g of Raney nickel catalyst in 40 mL of isopropanol until nitrogen evolution ceased. The solution was filtered and concentrated in vacuo at 40° C. to give 2.5 g of crude N-isopropyl-D-alanine amide.
Sources & evidence
- ORD record
- ord-c1bd4402b8b44aa5ba07056321703725
- Source dataset
- uspto-grants-1989_08
- Patent number
- US04855455
Reaction notes
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