Dimethylamine → 3-Fluoro-4,5-bis(phenylmethoxy)benzeneacetonitrile

Participants

Reaction Steps

A process for the preparation of the benzylcyanide compound of the formula I ##STR21## is prepared by: (a) converting the 2-fluoro-6-methoxyphenol compound of the formula II ##STR22## into the N,N-dimethyl-4-hydroxy-3-methoxy-5-fluorobenzylamine compound of the formula III by treating with formaldehyde and N,N-dimethylamine; ##STR23## (b) treating the benzylamine compound of the formula III by treating with methyliodide and displacement with NaCN, into the 3-methoxy-4-hydroxy-5-fluorobenzylnitrile compound of formula IV ##STR24## (c) treating the benzylnitrile compound of the formula IV with BBr3, followed by dibenzylation of the resulting catechol 3,4-dihydroxy-5-fluorobenzylcyanide compound of the formula V ##STR25## with benzylchloride to give the 3,4-dibenzyloxy-5-fluorobenzylcyanide compound of the formula I, ##STR26##

Provenance & Evidence