Dichloromethane → HCID 20026881, compound

Participants

Reaction Steps

A mixture of 3.72 g of 5-bromoacetyl-8-benzyloxycarbostyril, 3.3 g of N-(2-(p-methoxyphenyl)-1-methylethyl)amine, 2.6 g of sodium bicarbonate, 10 ml of methylene chloride and 2 ml of dimethylformamide is refluxed for 30 minutes under stirring. The mixture is concentrated under reduced pressure to remove solvent. The residue is extracted with chloroform, and the extract is washed with 10% hydrochloric acid, dried and then concentrated under reduced pressure to remove solvent. The residue is rcrystallized form a mixture of ethanol and isopropanol. 3.53 g of 8-benzyloxy-5-{1-oxo-2-[N-(2-(p-methoxypheyl)-1-methylethyl)amino]ethyl}carbostyril hydrochloride are obtained as colorless needles. Yield: 71.6%

Provenance & Evidence