Calcium Carbonate → HCID 13782697, compound

Participants

Reaction Conditions

Reaction Steps

36 g of β-chloroethyl chloroformate are added dropwise to 59.5 g of 4-amino-2-nitrophenyl tetrahydrofurfuryl ether of the formula V (obtainable according to A.1. or A.2.) and 14 g of calcium carbonate in 200 ml of 1,2-dimethoxyethane at 70° C. The mixture is then stirred at 80° C. for 1 hour, the inorganic salts are removed at elevated temperature, and the filtrate is evaporated to dryness. The remaining oil completely crystallizes after a short time; the crystals are triturated with 50 ml of ether, filtered off with suction, washed with a little ether, and dried. 75.8 g (88% of the theoretical figure) of 4-(β-chloroethoxycarbonyl)amino-2-nitrophenyl tetrahydrofurfuryl ether are obtained with a melting point of 84°-86° C.

Provenance & Evidence