Phenacyl bromide → (R)-2-Bromo-1-phenylethanol

Participants

Reaction Steps

The procedure as in Example 3 was repeated except that 7.5 g of 2-bromo-acetophenone was employed as a substrate in place of 7.5 g of 2-chloro-acetophenone to give 4.2 g of (S)-2-bromo-1-phenyl ethanol (b.p. 85° C./0.5 mmHg). The product had a specific rotatory power [α]D25 +48.7° (C=1, chloroform) and an optical purity of 97% enantiomer excess by an HPLC analysis.

Provenance & Evidence