Sodium Chloride → HCID 14025172, compound

HRID 1722630Notes

Reaction equation

HRID 1722630 reaction equation
[CH:1]([C:3]1[NH:4][C:5]([CH3:30])=[C:6]([P:23]2(=[O:29])[O:28][CH2:27][CH2:26][CH2:25][O:24]2)[CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])[C:8]=1[C:9]([O:11][CH3:12])=[O:10])=[O:2].[B-].[Na+].[Cl-].[Na+]>CO>[OH:2][CH2:1][C:3]1[NH:4][C:5]([CH3:30])=[C:6]([P:23]2(=[O:29])[O:24][CH2:25][CH2:26][CH2:27][O:28]2)[CH:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:21])([F:22])[F:20])[C:8]=1[C:9]([O:11][CH3:12])=[O:10]

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 14025169HCID 14025169, compoundHCID 22959485Vertellus

Product 1

HCID 14025172HCID 14025172, compoundYield 60.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The 2-formyl compound (1.06 g) obtained in Example 5 was dissolved in 7 ml of methanol and, with ice cooling and stirring, 90 mg of sodium borohydrate was added thereto. After stirring for 1 hour, 20 ml of sodium chloride solution was added to the reaction solution, extracted with chloroform, the chloroform layer was washed with water, dried, concentrated, and the residue was purified by a flash chromatography to give 0.64 g of pale yellow powder.

Workup

  1. stirringAfter stirring for 1 hour
  2. extractionextracted with chloroform
  3. washthe chloroform layer was washed with water
  4. customdried
  5. concentrationconcentrated
  6. customthe residue was purified by a flash chromatography

Sources & evidence

ORD record
ord-dbd5932862f5423cb951c05f1a353ca8
Source dataset
uspto-grants-1989_08
Patent number
US04857515

Reaction notes

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