反应详情

温度

5 °C

To a solution of tetraethyl [(2-benzo[b]thiophenecarboxamido)methylene]bis(phosphonate) (463 mg) in methylene chloride (2 ml) was added iodotrimethylsilane (1 ml) in one portion at 5° C. The mixture was stirred for one hour at 5° C., allowed to stand for 2 days in a refrigerator and then additionally stirred for one hour at ambient temperature. The mixture was extracted with water. The aqueous layer was washed with methylene chloride and diethyl ether and then evaporated under reduced pressure. The residue was dissolved in water and therein tert-butylamine (183 mg) was added. The mixture was lyophilized to give bis(tert-butylamine)salt of [(2-benzo[b]thiophenecarboxamido)methylene]bis(phosphonic acid) (277 mg) as a white powder.

1. waitto stand for 2 days in a refrigerator
2. stirringadditionally stirred for one hour at ambient temperature
3. extractionThe mixture was extracted with water
4. washThe aqueous layer was washed with methylene chloride and diethyl ether
5. customevaporated under reduced pressure
6. dissolutionThe residue was dissolved in water
7. additiontert-butylamine (183 mg) was added