Succinic Acid → HCID 14770397, compound

Participants

Reaction Steps

To a solution of 2.0 g (6.16 m mol) of 5-hydroxy-2,2,4,6,7 -pentamethyl-3-(4-isopropylphenyl)-2,3-dihydrobenzofuran obtained in Example 20 in 10 ml of dibutyl ether were added 740 mg (7.4 m mol) of anhydrous succinic acid and 0.1 ml of conc. sulfuric acid. This was stired at 80° C. for 1 hour. After cooling, the reaction mixture was washed with water, dried and concentrated. The resulting residue was purified by silica gel chromatography (eluted by isopropyl ether). Addition of isopropyl ether-hexane to the resulting concentrate gave 620 mg (yield 23.7%) of 3[3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yloxycarbonyl]propionic acid. mp. 141°-142° C.

Provenance & Evidence