Morpholine → HCID 14213086, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl hydrogen (α, α-dimethylbenzyl)malonate (4 g, 0.016 mol) in toluene was added triethylamine (2.33 ml, 0.016 mol) and diphenylphosphoryl azide (4.4 g, 0.016 mol). The reaction mixture was heated at 100° C. for 2.5 h, cooled to 5° C., and treated with 1.4 ml (0.016 mol) of morpholine. After stirring overnight at room temperature, the toluene solution was washed successively with 1N HCl and aqueous sodium bicarbonate solution. The dried organic solution was evaporated to a residue which was purified by column chromatography on silica gel. There was obtained 3.7 g (69%) of product after trituration with hexane, mp 93°-94° C.

Provenance & Evidence