Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | 1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-N-methyl-4-piperidinamine | HCID 15595033 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70387897 | HCID 70387897 | — |
Reaction Steps
A mixture of 10.1 g (0.03 mole) of 1-[1-[(4-fluorophenyl)methyl]-2(1H)-benzimidazolyl]-N-methyl-4-piperidinamine with 1.4 g (0.032 mole) of cyanamide and 1.8 g (0.03 mole) of acetic acid is heated to 135° C. for 1.5 hours. The mixture is cooled and it is then taken up with methylene chloride under reflux, and the precipitate is filtered off and then dried. N-[1-[1-[(4-fluorophenyl)methyl]-2(1H)-benzimidazolyl]-4-piperidinyl]-N-methylguanidine acetate is thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04857536 |
|---|
| Source dataset | uspto-grants-1989_08 |
|---|
| ORD ID | ord-f71c931170154a07814df7b308ba69f2 |
|---|
| Source note | uspto-grants-1989_08 |
|---|
