反应详情

In a process analogous to Example 1 by substituting 4-(2-propynylamino)benzonitrile (see Example F) for 1-[4-(2-propynylamino)phenyl]ethanone and N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide (Journal of Heterocyclic Chemistry, Vol. 12, pp. 1283-1286 (1975)) for 2,2-dimethylpropanoic acid, [6-(bromomethyl)-4-oxo-3(4H)-quinazolinyl]methyl ester (European patent application No. 204,529) one obtains 4-[[[2-[(2,2-dimethyl-1-oxopropyl)amino]-3,4-dihydro-4-oxo-6-quinazolinyl]methyl]-2-propynylamino]benzonitrile; mp 183°-186° C.