Ammonia → 6-[[(4-Acetylphenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone

Participants

Reaction Steps

To 2.34 g (5.25 mmol) of 2,2-dimethylpropanoic acid, [6-[[(4-acetylphenyl)-2-propynylamino]methyl]-4-oxo-3(4H)-quinazolinyl]methyl ester (Example 1) is added a solution of 500 ml of methanol saturated with ammonia at 20° C. The solution is stirred at room temperature for eighteen hours. The solution is concentrated to give a solid which is recrystallized from ethanol to give the product as a pink solid; mp 197°-199° C.

Provenance & Evidence