1-Dimethylaminomethyl-1-(2-thienyl)-1-propanol → 1-Dimethylaminomethyl-1-(2-thienyl)propyl 3-(3,4,5-trimethoxyphenyl)propionate

HRID 1722733Notes

Reaction equation

HRID 1722733 reaction equation
[CH3:1][N:2]([CH2:4][C:5]([C:9]1[S:10][CH:11]=[CH:12][CH:13]=1)([OH:8])[CH2:6][CH3:7])[CH3:3].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH2:26][CH2:27][C:28](Cl)=[O:29])[CH:19]=[C:20]([O:24][CH3:25])[C:21]=1[O:22][CH3:23]>>[CH3:25][O:24][C:20]1[CH:19]=[C:18]([CH2:26][CH2:27][C:28]([O:8][C:5]([CH2:4][N:2]([CH3:3])[CH3:1])([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH2:6][CH3:7])=[O:29])[CH:17]=[C:16]([O:15][CH3:14])[C:21]=1[O:22][CH3:23]

Participants

3

Reactant 2

HCID 146500501-Dimethylaminomethyl-1-(2-thienyl)-1-propanolHCID 146500973-(3',4',5'-Trimethoxyphenyl)propionyl chloride

Product 1

HCID 146500571-Dimethylaminomethyl-1-(2-thienyl)propyl 3-(3,4,5-trimethoxyphenyl)propionateYield 51.9%

Procedure

1-Dimethylaminomethyl-1-(2-thienyl)-1-propanol (1.12 g) and 3-(3,4,5-trimethoxyphenyl)propionyl chloride (1.61 g) are treated in the same manner as described in Example 1-(2), whereby 1-dimethylaminomethyl-1-(2-thienyl)propyl 3-(3,4,5-trimethoxyphenyl)propionate (1.23 g) is obtained as colorless oil.

Sources & evidence

ORD record
ord-e7b626e7a4804b4fb08f6104ea8f65ef
Source dataset
uspto-grants-1989_08
Patent number
US04857543

Reaction notes

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