5-(5-Bromopentyl)-3-methylisoxazole → HCID 515426, compound

HRID 1722747Notes

Reaction equation

HRID 1722747 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[CH:5]=[C:4]([Cl:13])[C:3]=1[OH:14].Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[O:25][N:24]=[C:23]([CH3:26])[CH:22]=1>>[Cl:13][C:4]1[CH:5]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:2]([Cl:1])[C:3]=1[O:14][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[O:25][N:24]=[C:23]([CH3:26])[CH:22]=1

Participants

3

Reactant 2

HCID 135440465-(5-Bromopentyl)-3-methylisoxazoleHCID 20027406HCID 20027406, compound

Product 1

HCID 515426HCID 515426, compoundYield 40%

Procedure

5-{5-[2,6-Dichloro-4-(2-furanyl)phenoxy]pentyl}-3-methylisoxazole [II; R1 and R2 =Cl, Het=2-furanyl] was prepared from 2,6-dichloro-4-(2-furanyl)phenol and 5-(5-bromopentyl)-3-methylisoxazole according to the procedure of Example 1(c), and was obtained in about 40% yield as a pale-yellow oil which could be caused to crystallize from isopropyl acetate-hexane as a pale-yellow solid, m.p. 29-30° C.

Workup

  1. customwas obtained in about 40% yield as a pale-yellow oil which
  2. customto crystallize from isopropyl acetate-hexane as a pale-yellow solid, m.p. 29-30° C.

Sources & evidence

ORD record
ord-bcee37ce81734977bc99b1afa8f43aab
Source dataset
uspto-grants-1989_08
Patent number
US04857539

Reaction notes

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