Chloroacetaldehyde → HCID 6483424, compound

Participants

Reaction Steps

A suspension of 7.5 g 5-[5(4-thiocarbamylphenoxy)pentyl]-3-methylisoxazole and 24.6 g chloroacetaldehyde (50% in water) in 150 ml absolute ethanol was refluxed for 3.5 hours. The reaction mixture was concentrated in vacuo and the residue recrystallized from ethyl acetate-hexane to give 4.5 g 3-methyl-5-{5-[4-(2-thiazolyl)phenoxy]pentyl}isoxazole, m.p. 78-80° C.

Provenance & Evidence