HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-[5-(3-Methyl-5-isoxazolyl)pentyloxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-(5-Bromopentyl)-3-methylisoxazole | HCID 13544046 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[5-(3-Methyl-5-isoxazolyl)pentyloxy]benzaldehyde | HCID 6483425 | 67% |
Reaction Steps
A solution of 7.2 g 4-hydroxybenzaldehyde, 14.6 g 5-(5-bromopentyl)-3-methylisoxazole, 4 g potassium hydroxide in 100 ml acetonitrile was heated at reflux for 1.5 hours. The reaction mixture was cooled and filtered the solvent removed, and the residue recrystallized from isopropyl acetate-hexane to give 10.8 g 4-[5-(3-methyl-5-isoxazolyl)pentyloxy]benzaldehyde as a pale-yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857539 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-811854fde7ae4735af79218f6b716a47 |
| Source note | uspto-grants-1989_08 |