HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cysteamine → 3-Methyl-5-{5-[4-(2-thiazolidinyl)phenoxy]pentyl}isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cysteamine | HCID 6058 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 4-[5-(3-Methyl-5-isoxazolyl)pentyloxy]benzaldehyde | HCID 6483425 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methyl-5-{5-[4-(2-thiazolidinyl)phenoxy]pentyl}isoxazole | HCID 54231038 | 39.7% |
Reaction Steps
A solution of 4.00 g of 4-[5-(3-methyl-5-isoxazolyl)pentyloxy]benzaldehyde (Example 35a), 1.22 g of 2-aminoethanethiol and a trace of p-toluenesulfonic acid in 30 ml of toluene was heated at reflux for 2 hours using a Dean-Stark trap. The product was isolated and recrystallized from isopropyl acetate-hexane to give 1.93 g of the above-indicated product, m.p. 82-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857539 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-31b7c2b1b09d4e349e8ff3afac464ce9 |
| Source note | uspto-grants-1989_08 |