Water → HCID 516125, compound

Participants

Reaction Steps

A solution of 8.0 g 5-{5-[2,6-dimethyl-4- (2-methoxycarbonylmethyl-2H-tetrazol-5-yl)phenoxy]pentyl}-3-methylisoxazole (Example 52) in 50 ml tetrahydrofuran was added dropwise to a stirred suspension of 0.53 g lithium aluminum hydride in 250 ml dry tetrahydrofuran under nitrogen with cooling in an ice bath. The reaction mixture was allowed to come to room temperature and then treated with water and 15% sodium hydroxide. Isolation of the product provided 6.56 g (88%) of 5-{5-[2,6-dimethyl-4-[2-(2-hydroxyethyl)-2H-tetrazol-5-yl]phenoxy]pentyl}-3-methylisoxazole, m.p. 69-70° C. (from 2-propanol/hexane).

Provenance & Evidence