HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → N-(2-morpholin-4-ylethyl)-3-oxobutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 2-Morpholinoethylamine | HCID 408285 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(2-morpholin-4-ylethyl)-3-oxobutanamide | HCID 4076516 | — |
Reaction Steps
To a solution of diketene (23.0 ml) in diethyl ether (115 ml) was added dropwise a solution of N-(2aminoethyl)morpholine (34.7 g) in diethyl ether (300 ml) at -40° C. After stirring for 2 hours at the same condition, the resulting precipitates were collected by filtration and dried in vacuo to give N-(2morpholinoethyl)acetoacetamide (41.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857527 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-677f3f25c1d74e48aec7fe1e765794b7 |
| Source note | uspto-grants-1989_08 |