1-(3-Chlorophenyl)piperazine → HCID 131716036, compound

Participants

Reaction Steps

The title compound is prepared by adding to a stirred solution of 2-fluorenesulfonylchloride (4 g, 0.015 mol) in 50 mL of methylene chloride, 1-(3-chlorophenyl)piperazine (3 g, 0.013 mol) and triethylamine (6 mL). The solution is stirred overnight and the methylene chloride layer is washed with water and dried over anhydrous Na2SO4. Evaporation of the methylene chloride under reduced pressure affords crude product which is purified as in Example 2 and converted to the hydrochloride salt; m.p. 219°-221° C. (35% yield).

Provenance & Evidence