HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(4-Aminophenyl)-3-cyclohexylmethyl-3-azabicyclo[3.1.1]heptane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Cyclohexylmethyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872618 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 1-(4-Aminophenyl)-3-cyclohexylmethyl-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872625 | — |
Reaction Steps
In a manner analogous to that described in Example 1a, 6.0 g of 3-cyclohexylmethyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 120 ml of 2-methoxyethanol, hydrogenated in the presence of 0.6 g of 5% palladium-on-carbon and worked up. Melting point 140°-146° (from ether). Rf (ether)=0.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857660 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-bb832074901a41d18643e88384edfb52 |
| Source note | uspto-grants-1989_08 |