HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872633 | — |
| Reactant | Diethylether ethylacetate | HCID 21584169 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872638 | — |
Reaction Steps
In a manner analogous to that described in Example 1a, 2.46 g of 3-benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 50 ml of ethyl acetate, hydrogenated in the presence of 0.3 g of 5% palladium-on-carbon and worked up. Melting point 164°-165.5° (from ether/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857660 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-365b79053de1453ab05f380dab124652 |
| Source note | uspto-grants-1989_08 |