HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-ethyl-3-azabicyclo[3.1.1]heptane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 20027840 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Aminophenyl)-3-ethyl-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 20027809 | — |
Reaction Steps
In a manner analogous to that described in Example 1a, 2.33 g of 3-ethyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 70 ml of methanol are hydrogenated in the presence of 0.15 g of palladium-on-carbon and worked up. Melting point 159°-162° (from ethyl acetate/petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04857660 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-fb7881bcdcf942e6bb295c12c45799d0 |
| Source note | uspto-grants-1989_08 |