反应详情

To a mixture of concentrated sulfuric acid (20 ml) and water (30 ml) at room temperature, there was added 1-(4-iodophenyl)cyclopropanecarbonitrile (7.0 g, 0.026 m). The reaction mixture was refluxed for 15 hrs under nitrogen atmosphere. The reaction mixture was cooled to room temperature and extracted with ether-chloroform mixture (4×100 ml). The organic layer was washed with water (2×50 ml), brine (50 ml) and dried over magnesium sulfate. The solvent was removed to give 7.2 g of product (96% yield; M.P. 150°-152° C.). ##STR5## Xn =2-chloro, 6-fluoro.

1. temperatureThe reaction mixture was refluxed for 15 hrs under nitrogen atmosphere
2. extractionextracted with ether-chloroform mixture (4×100 ml)
3. washThe organic layer was washed with water (2×50 ml), brine (50 ml)
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed