Ethyl piperidine-2-carboxylate → HCID 20026157, compound

Participants

Reaction Steps

2.9 g 4-Chloro-5-(2,2-difluorocyclopropylmethoxy)-2-fluorophenyl isothiocyanate was dissolved in 20 ml hexane and added dropwise to a solution of 1.5 ml ethyl piperidine-2-carboxylate in 10 ml hexane. The mixture heated under reflux for 2 hours. The solvent was removed and the residue was chromatographed on silica gel using a mixture of 3 parts hexane and 1 part ethyl acetate.

Provenance & Evidence