Diglyme → HCID 20026156, compound

Participants

Reaction Steps

1.2 g N-[4-Chloro-2-fluoro-5-vinyloxyphenyl)-3,4,5,6-tetrahydrophthalimide was dissolved in 5 ml diethylene glycol dimethyl ether, the mixture was heated to reflux and a solution of 2.8 g sodium chlorodifluoroacetate in 5 ml diethylene glycol dimethyl ether was added slowly. The mixture was heated under reflux for 5 hours, then separated from the sodium chloride, which formed, and the solvent removed. The residue was chromatographed on silica gel using a mixture of hexane/diethyl ether=1:1.

Provenance & Evidence