Triethyl orthoacetate → HCID 178467933, compound

HRID 1722927Notes

Reaction equation

HRID 1722927 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7]([NH:10][C:11]2[C:16]([Cl:17])=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:18])(=[O:9])=[O:8])[N:3]=1.[C:19](OCC)(OCC)([O:21][CH2:22][CH3:23])[CH3:20]>C(#N)C.C(O)(=O)C>[Cl:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([Cl:17])[C:11]=1[NH:10][S:7]([C:4]1[N:3]=[C:2]([N:1]=[C:19]([O:21][CH2:22][CH3:23])[CH3:20])[NH:6][N:5]=1)(=[O:9])=[O:8]

Participants

5

Reactant 2

HCID 66221Triethyl orthoacetateHCID 178509071HCID 178509071, compound

Product 1

HCID 178467933HCID 178467933, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 6342AcetonitrileSolvent

Procedure

6.16 g (20.0 mmol) 5-amino-N-(2,6-dichlorophenyl)-1H-1,2,4-triazole-3-sulphonamide was heated in 50 ml acetonitrile with 4.2 ml (23.0 mmol) triethyl orthoacetate and 3 drops glacial acetic acid for 5 hours under reflux. The mixture was cooled and evaporated to dryness. The residue was recrystallized from ethyl acetate.

Workup

  1. temperatureunder reflux
  2. temperatureThe mixture was cooled
  3. customevaporated to dryness
  4. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-d0b926bcef5a4cb6b6070fb71f665ef6
Source dataset
uspto-grants-1989_08
Patent number
US04859231

Reaction notes

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