HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetyl chloride | HCID 6367 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine | HCID 737272 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole | HCID 14255122 | — |
Reaktionsschritte
To 30 g (0.145 mol) 5-amino-3-benzylthio-1H-1,2,4-triazole and 25 ml triethylamine in 300 ml methylene chloride, 12.57 g (0.16 mol) acetyl chloride in 30 ml methylene chloride was added dropwise. It was then stirred at room temperature for 30 minutes, treated with 160 ml 1N caustic soda and the product extracted with methylene chloride. After drying it was recrystallised from ethyl acetate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04859231 |
| Quelldatensatz | uspto-grants-1989_08 |
| ORD ID | ord-750e84dd79d44b36b62808683548c0fc |
| Quellennotiz | uspto-grants-1989_08 |