HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate → 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-fluoromethyl-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate | HCID 13272924 | — |
| Reactant | Ethyl 3-amino-2,4-difluorocrotonate | HCID 86742181 | — |
| Product | 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-fluoromethyl-2,4(1H,3H)-pyrimidinedione | HCID 20025988 | — |
Reaction Steps
using ethyl 3-amino-2,4-difluorocrotonate and 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-fluoromethyl-2,4(1H,3H)-pyrimidinedione, m.p. 152°-154° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04859229 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-f668c2085f564acc9a2f8a911a91faf2 |
| Source note | uspto-grants-1989_08 |