Dimethyl Sulfate → HCID 20026004, compound

HRID 1722949Notes

Reaction equation

[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([CH3:20])[NH:14][C:13]2=[O:21])=[C:4]([F:22])[CH:3]=1.S(OC)(O[CH3:27])(=O)=O>>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([CH3:20])[N:14]([CH3:27])[C:13]2=[O:21])=[C:4]([F:22])[CH:3]=1

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 20025954HCID 20025954, compound

Product 1

HCID 20026004HCID 20026004, compound

Procedure

using 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6 methyl-2,4(1H,3H)-pyrimidinedione and dimethyl sulphate there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-1,6-dimethyl-5-fluoro-2,4(1H,3H)pyrimidinedione, m.p. 139°-141° C.;

Sources & evidence

ORD record: ord-9e085d2a8853412d8596c5c8da3d5b3a
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

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