Dimethyl Sulfate → HCID 20026026, compound

HRID 1722950Notes

Reaction equation

[CH2:1]([C:3]1[NH:8][C:7](=[O:9])[N:6]([C:10]2[CH:15]=[C:14]([O:16][CH:17]([CH3:19])[CH3:18])[C:13]([Cl:20])=[CH:12][C:11]=2[F:21])[C:5](=[O:22])[CH:4]=1)[CH3:2].S(OC)(O[CH3:27])(=O)=O>>[CH2:1]([C:3]1[N:8]([CH3:27])[C:7](=[O:9])[N:6]([C:10]2[CH:15]=[C:14]([O:16][CH:17]([CH3:19])[CH3:18])[C:13]([Cl:20])=[CH:12][C:11]=2[F:21])[C:5](=[O:22])[CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 20026031HCID 20026031, compound

Product 1

HCID 20026026HCID 20026026, compound

Procedure

using 6-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2,4 (1H,3H)-pyrimidinedione and dimethyl sulphate there is obtained 6-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-1-methyl-2,4(1H,3H)-pyrimidinedione, m.p. 72°-74° C.;

Sources & evidence

ORD record: ord-999bfa9fdf8647f580b77facee0798e9
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

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