Dimethyl Sulfate → HCID 20026132, compound

HRID 1722952Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:23])[N:5]([C:11]2[CH:16]=[C:15]([O:17][CH:18]([CH3:20])[CH3:19])[C:14]([Cl:21])=[CH:13][C:12]=2[F:22])[C:6](=[O:10])[NH:7][C:8]=1[CH3:9])[CH3:2].S(OC)(O[CH3:28])(=O)=O>>[CH2:1]([C:3]1[C:4](=[O:23])[N:5]([C:11]2[CH:16]=[C:15]([O:17][CH:18]([CH3:19])[CH3:20])[C:14]([Cl:21])=[CH:13][C:12]=2[F:22])[C:6](=[O:10])[N:7]([CH3:28])[C:8]=1[CH3:9])[CH3:2]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 20026107HCID 20026107, compound

Product 1

HCID 20026132HCID 20026132, compound

Procedure

using 5-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-methyl-2,4(1H,3H)-pyrimidinedione and dimethyl sulphate there is obtained 5-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-1,6-dimethyl-2,4(1H,3H)-pyrimidinedione, m.p. 124°-125° C.;

Sources & evidence

ORD record: ord-f9fe326f99714cd596fd3a356d6546e6
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

Loading…