Ethyl chloroformate → 1-ethoxycarbonyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

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Reaction Steps

using 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with potassium carbonate and ethyl chloroformate in acetone there is obtained 1-ethoxycarbonyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione, 1H-NMR (CDCl3, 400 MHz): 7.30 ppm (d,1H), 6.83 ppm (d,1H), 6.37 ppm (s,1H), 4.51 ppm (q,2H), 4.45 ppm (m,1H), 1.42 ppm (t,3H), 1.37 ppm (d,6H);

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