Pyridine → HCID 53751461, compound

HRID 1722960Notes

Reaction equation

HRID 1722960 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]2=[O:24])=[C:4]([F:25])[CH:3]=1.[C:26](Cl)(=[O:28])[CH3:27].N1C=CC=CC=1>C(OCC)C>[C:26]([O:11][CH2:10][CH2:9][O:8][C:7]1[CH:6]=[C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]2=[O:24])[C:4]([F:25])=[CH:3][C:2]=1[Cl:1])(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 20025916HCID 20025916, compound

Product 1

HCID 53751461HCID 53751461, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

using 3-[4-chloro-2-fluoro-5-(2-hydroxyethoxy)-phenyl]-1-methyl-6 -trifluoromethyl-2,4(1H,3H)-pyrimidinedione and acetyl chloride with pyridine in diethyl ether there is obtained 2-{2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidinyl]-4-fluorophenoxy}-ethyl acetate, m.p. 88°-90° C.;

Sources & evidence

ORD record
ord-2d171e9e42004b379b83314a7349c1db
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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