Sodium hydride → {2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl}-1-piperidinecarboxylate

関与物質

反応手順

using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with N-chlorocarbonyl-piperidine and sodium hydride in dimethylformamide there is obtained {2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidinyl]-4-fluorophenyl}-1-piperidinecarboxylate, 1 -NMR (CDCl3, 400 MHz): 7.33 ppm (d,1H), 7.25 ppm (d,1H), 6.34 ppm (s,1H), 3.57°-3.69 ppm (m,2H), 3.53 ppm (d,3H), 3.44°-3.56 ppm (m,2H), 1.56°-1.70 ppm (m,6H);

情報源と証拠