Pyridine → HCID 20025915, compound

HRID 1722963Notes

Reaction equation

[Cl:1][C:2]1[C:7](O)=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1.C1(CC(Cl)=[O:31])C=CC=CC=1.N1C=[CH:37][CH:36]=[CH:35][CH:34]=1.[CH2:39]([O:41][CH2:42][CH3:43])[CH3:40]>>[C:39]([O:41][C:42]1[CH:37]=[CH:36][CH:35]=[CH:34][C:43]=1[C:7]1[CH:6]=[C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]([CH3:20])[C:10]2=[O:21])[C:4]([F:22])=[CH:3][C:2]=1[Cl:1])(=[O:31])[CH3:40]

Participants

Reactant 4

HCID 1049Pyridine

HCID 3283Diethyl Ether

HCID 7679Phenylacetyl chloride

HCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 20025915HCID 20025915, compound

Procedure

using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with phenylacetyl chloride and pyridine in diethyl ether there is obtained {2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4 -fluorophenyl}-phenyl acetate, 1H-NMR (CDCl3, 400 MHz): 7.27-7.40 ppm (m,6H), 7.10 ppm (d,1H), 6.33 ppm (s,1H), 3.89 ppm (s,2H), 3.53 ppm (d,3H);

Sources & evidence

ORD record: ord-f3172683ca7d4f6c951af530d1ea6bb0
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

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