HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 20025994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Butanoic acid, 4-(diethylamino)-4-oxo- (9CI) | HCID 15205 | — |
| Reactant | 4-Pyrrolidinopyridine | HCID 75567 | — |
| Reactant | 1-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione | HCID 11267757 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 20025994 | HCID 20025994 | — |
Reaction Steps
using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione and 3-(diethylcarbamoyl)-propionic acid with N,N'-dicyclohexylcarbodiimide and 4-pyrrolidino-pyridine as the catalyst in methylene chloride there is obtained 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl 3-(diethylcarbamoyl)propionate, m.p. 91°-93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04859229 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-a32c9986a0cc45a7a9a32078928c908f |
| Source note | uspto-grants-1989_08 |