Pyridine → HCID 20025960, compound

HRID 1722974Notes

Reaction equation

HRID 1722974 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]2=[O:24])=[C:4]([F:25])[CH:3]=1.N1C=CC=CC=1.[CH2:32]([O:34]CC)C>>[CH:32]([O:11][CH2:10][CH2:9][O:8][C:7]1[CH:6]=[C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]2=[O:24])[C:4]([F:25])=[CH:3][C:2]=1[Cl:1])=[O:34]

Participants

4

Reactant 3

HCID 1049PyridineHCID 3283Diethyl EtherHCID 20025916HCID 20025916, compound

Product 1

HCID 20025960HCID 20025960, compound

Procedure

using 3-[4-chloro-2-fluoro-5-(2-hydroxyethoxy)phenyl]-1-methyl-6 -trifluoromethyl-2,4(1H,3H)pyrimidinedione with pyridine in diethyl ether there is obtained 2-{2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4 -trifluoromethyl-1(2H)-pyrimidinyl]-4 -fluorophenoxy}-ethyl formate, 1H-NMR (CDCl3, 400 MHz): 8.11 ppm (t,1H), 7.33 ppm (d,1H), 6.82 ppm (d,1H), 6.35 ppm (s,1H), 4.54 ppm (m,2H), 4.22 ppm (t,2H), 3.56 ppm (d,3H).

Sources & evidence

ORD record
ord-3b9154f46b01408d855bc46559aded95
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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